Toronto Eye Care has participated in many clinical studies including research on contact lenses, dry eye, ocular diagnostic technology and the impact of disease on the eye. Below are the most recent clinical studies at Toronto Eye Care:

1. The Measurement of Tear Osmolarity Using Two Different Instruments

  • In dry eye disease, the human tear film changes its physical and biochemical composition and displays an increase in osmolarity. This resultant characteristic of the dry eye tear film is universal but measuring it can be difficult. Drs. Nolfi and Caffery compared 2 different osmolarity measuring devices in healthy non-dry eye subjects. The results demonstrated that one instrument measured normal osmolarity much more accurately than the other. These results are being reviewed for publication.

2. Sjogren’s Syndrome

  • Sjogren’s syndrome is an autoimmune disease similar to rheumatoid arthritis with 90% of patients being female. Sjogren’s syndrome causes severe drying of the eyes and mouth and, surprisingly, we are unaware of how the eyes dry over time. Do they get very severe and stay that way? Do they wax and wane with the weather and general health? Do some people get worse dryness than others and if so how do we identify them? To answer these questions, Drs. Acs and Caffery started reviewing Sjogren’s charts and recording the many variables within the chart including assessment of dry eye. Along with 5 other sites in North America, variables were recorded and sent to a bio-statistician for analysis. These results will be published soon.
  • To further study the tears of Sjogren’s patients, Dr. Caffery, along with the research group at the University of Waterloo School of Optometry and Vision Science have collected tears from these patients for analysis. The tears were packed in dry ice and shipped to a lab at the University of Calgary where many proteins will be analyzed. By determining the differences in normal and Sjogren’s tears we can better understand the mechanism of the disease and work to find appropriate treatments.